Best leaving groups for organic reactions?
- Mayya Alocci
- Mar 5, 2018
- 1 min read
Updated: Nov 20, 2022
Most often encountered leaving groups are halogens (Group17). The larger the atomic radius the better of a leaving group halogen is and therefore, I- > Br-> Cl-
Water and OTs are great leaving groups as well.
Thus, according to the David Klein book here is the list of best to worse leaving groups.

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