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Best leaving groups for organic reactions?

  • Mayya Alocci
  • Mar 5, 2018
  • 1 min read

Updated: Nov 20, 2022


Most often encountered leaving groups are halogens (Group17). The larger the atomic radius the better of a leaving group halogen is and therefore, I- > Br-> Cl-

Water and OTs are great leaving groups as well.

Thus, according to the David Klein book here is the list of best to worse leaving groups.

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