top of page

Best leaving groups for organic reactions?

Most often encountered leaving groups are halogens (Group17). The larger the atomic radius the better of a leaving group halogen is and therefore, I- > Br-> Cl-

Water and OTs are great leaving groups as well.

Thus, according to the David Klein book here is the list of best to worse leaving groups.

Organic chemistry tutor NYC


Ready For Chemistry Tutoring?

I tutor all levels of chemistry including general and organic chemistry.

Click To Learn More

bottom of page