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Organic Chemistry by Brown, Iverson, Anslyn, Foote | Mayya's Study Guide | Chapter 8

Chapter 7: Haloalkanes, Halogenation, and Radical Reactions


Table of contents of main topics:

  • Preparation of Haloalkanes by Halogenation of Alkanes

  • Allylic Halogenation

  • Radical Autoxidation

  • Radical Addition of HBr to Alkenes


1. Preparation of Haloalkanes by Halogenation Of Alkanes


Reagent: Br2, light.

Product: Adds Br to the most substituted carbon on the alkane


Radical bromination of an alkane
Radical bromination of an alkane

Mechanism

Radicals contain at least one unpaired electron. The arrows that we draw for

radical reaction mechanisms are different from regular arrows.


Radical arrow: breaking and making a bond
Radical arrow: breaking and making a bond

Radical reactions generally have 3 steps in their mechanism:

  1. Initiation (making a radical)

  2. Propagation (making the desired product)

  3. Termination (getting rid of all the radicals)


In the mechanism, the first step is initiation. The bond between Br-Br breaks to give us two Br radicals.

Propagation is made up of 2 steps. First, we draw the alkane starting material. Bond between hydrogen and carbon breaks (on the carbon we want to attach Br to) and bromine radical forms a bond with hydrogen, resulting in HBr and alkane radical. In the second step, alkane radical reacts with Br-Br. The bond between Br-Br breaks and the alkane radical forms a bond with the bromine to give the desired product.

Termination is used to get rid of any radical created in the reaction. During termination any radicals created in the reaction come together and make a bond.

mechanism of radical bromination of an alkane
mechanism of radical bromination of an alkane

Please note that this reaction is also possible with Cl2 and light. However, chlorine is not selective like bromine and can attach to any carbon, allowing for many different products to form.


2. Allylic Halogenation

Allylic carbon is a carbon that is next to a C=C. Allylic halogenation is a reaction that adds bromine to an allylic carbon.


Reagent: NBS, light